Evaluation of the Sildenafil Effect on Female Sexual Dysfunction

Document Type : Original Article


1 Dermatology,Venereology& Andrology department, Faculty of Medicine, Zagazig University

2 Department of Dermatology,Venereology & Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt


Background : Female Sexual Dysfunction (FSD) is a disturbance or dysfunction in the process of desire, arousal or orgasm which can be a symptom of a biological condition, a psychological problem or an interpersonal issue or a combination of these factors. Female Sexual Dysfunction is a multi-causal and a multi-dimensional medical problem that adversely affects physical health & emotional wellbeing. Also impaired sexual function has damaging effects on the self esteem, sense of wholeness and interpersonal relationships of women. It is often emotionally distressing and might lead to familial discord and divorce, and reproduction is also affected. Sildenafil is selective type 5 phosphodiesterase (PDE5) inhibitors , taken orally and effective for men with erectile dysfunction. Previous studies suggested that sildenafil, which acts by inhibiting cyclic GMP specific PDE5, may improve the sexual health of women affected by sexual difficulties such as arousal disorders and may indirectly improve other aspects of sexual life. Sildenafil was effective and well tolerated in post menopausal women with sexual arousal disorder without concomitant hypoactive sexual desire disorder or contributory emotional relationship or historical abuse issues.  Objective: This study aims to evaluate the effect of sildenafil citrate on female sexual dysfunction.  Subjects and Methods: The study was conducted in Dermatology,Venereology, and Andrology department, Faculty of Medicine, Zagazig University Hospitals during the period from April 2015 to August 2016. Twenty six married female patients were included in this study. Patients were divided into two groups. Group 1 contains thirteen patients took 50mg sildenafil on demand and group 2 contains thirteen patients took placebo.  Results: There was no significant differences between the studied groups regarding the demographic data, and FSFI scors. There was significant differences between pre and post treatment of sexual dysfunction scors regarding group І. There was no significant differences in post treatment results between the two studied groups as regard sexual dysfunction except in orgasm and pain.  Conclusions: Sildenafil citrate may be effective in women who couldn’t achieve orgasm and decrease pain in patients with dysparunia.