Evaluation of the Role of estrogen receptor alpha gene polymorphism in female sexual function : A case controlled study

Document Type : Original Article


1 Dermatology, Venereology and Andrology department, Faculty of Medicine, Suez Canal University.

2 Departments of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Egypt

3 Dermatology department, Ismailia General Hospital

4 lecturer of andrology, faculty of medicine suez canal university, Ismalia, egypt


Introduction: Female sexual dysfunction is a common problem with serious effects on women’s quality of life. The biological effects of estrogens are mediated primarily through high-affinity binding to estrogen receptors. The association between estrogen receptor genes and sexual desire and arousal in women has not yet been specifically studied.

Aim: To assess estrogen receptor alpha gene polymorphism in females with sexual dysfunction and to detect its relationship with sexual dysfunction in females.

Methods: A case-control study was conducted on 48 women divided into two groups: 24 women with sexual dysfunction and 24 healthy women as a control group. Sexual function of all participants was evaluated using The Female Sexual Function Index. Estrogen receptor alpha gene polymorphism was assessed using polymerase chain reaction and Horizontal gel electrophoresis.

Results: The largest percent of cases aged from 25 to less than 30 years old (79%) while in controls, the largest percentages aged from (20-


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