Egyptian Society of AndrologyHuman Andrology2090-60489320190901Bisphenol A as a potential hazardous compound on male reproductive function : A mini-review657012098510.21608/ha.2020.21245.1052ENMohamed AhmedAbd El SalamDepartment of Andrology, Sexology and STDs, Faculty of Medicine, Cairo University, Giza, EgyptNadaEl Sayed SelimDepartmentof Andrology, Sexology and STDs, Faculty of Medicine, Cairo University, Cairo, EgyptJournal Article20191220Background: Male factor infertility contributes for ~50% of the overall cases of infertility. Several causes have been attributed to male factor infertility,which may be pre-testicular, testicular, or post-testicular factors. Exposure to gonadotoxins is nowadays an increasing etiology of male factor infertility,at either the environmental or occupational levels. One of the commonly encountered gonadotoxins is bisphenol A, a xenoestrogen that carries a potential risk on male fertility potential at various levels in several animal species and humans, thus negatively affecting the reproductive capacity (i.e. Spermatogenesis and steroidogenesis) as well as deteriorating sperm quality and functions. Besides that, growing evidence has shown that it may carry a hazardous risk that may lead to other health problems and diseases, such as diabetes, obesity, thyroid dysfunction, cardiovascular diseases, and cancer. Hereby, we focus on the negative effect of bisphenol A exposure on male reproductive function with an up-to-date review of literature.Egyptian Society of AndrologyHuman Andrology2090-60489320190901Impact of isotretinoin treatment on testosterone and sex hormone-binding globulin in malepatients with acne vulgaris717612098710.21608/ha.2020.15139.1048ENYasser SalemNasrallahdermatology and andrology, faculty of medicine, suez canal university.0000-0003-1923-4213HalimMaher1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, EgyptMaha M.AnaniDepartment of Clinical Pathology, Faculty of Medicine, Suez Canal University Ismailia, EgyptMoustafa M.EyadaDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt and Shaqra University, Saudi Arabia,Journal Article20190724Background: Acne vulgaris is primarily a disease of the pilosebaceous unit. Four main pathogenic factors are known to lead to its development: follicular epidermal hyperproliferation, excess sebum production, inflammation, and the activity of propionibacterium acnes. Isotretinoin (ISO) is a 13-cis-retinoic acid derivative of vitamin A. It is a highly effective therapy for severe nodulocystic acne.<br />Objective: The aim was to measure serum total, free testosterone, and sex hormone-binding globulin (SHBG) levels, before and after treatment, in male patients suffering from acne vulgaris and taking ISO as a treatment for their acne.<br />Patients and Methods: The authors included 113 male patients with acne vulgaris. The patients received 0.5░mg/kg/day ISO treatment. Blood samples were collected from the patients for analysis of total, free testosterone, and SHBG levels before and after 6 months of treatment.<br />Results: After 6 months of treatment with ISO, the total lesion count was significantly lower after treatment (88.70±35.04 and 27.80±17.94, respectively, P<0.05).There was significant reduction in mean total testosterone serum levels after treatment (5.553±2.614 and3.329±2.276, respectively, P<0.05).The mean free testosterone serum level was insignificantly lower after treatment (31.237±11.994 and 24.526±14.917, respectively, P>0.05), and the mean SHBG serum level was insignificantly higher after treatment (104.367±14.689 and105.533±16.362, respectively, P>0.05).<br />Conclusion: This study showed that ISO treatment led to significant reduction in serum total testosterone levels, which may be beneficial for tackling the pathogenesis of acneEgyptian Society of AndrologyHuman Andrology2090-60489320190901Role of serum androgens and prostate-specific antigen levels in males with androgenetic alopecia778412098910.21608/ha.2020.19072.1050ENHeshamKhaleddermatology and andrology department, faculty of medicine, menoufia universityAzza M.Abdu AllahMedical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Menoufia, EgyptAhmad A.AbdelhameedDepartments of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University,Wafaa A.ShehataDepartments of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia UniversityJournal Article20191103Background: Androgenetic alopecia (AGA) is the most common form of hair loss. It is caused by the continuous miniaturization of affected hair follicles. Genetic factors and androgenic factors especially dihydrotestosterone (DHT), which is a testosterone tissue metabolite, play major roles in the pathogenesis of AGA. Many studies suggest that AGA may be a marker of increased risk of prostate cancer.<br />Objective: The study aimed to examine the role of serum androgens and prostate-specific antigen (PSA) in males with AGA.<br />Patients and Methods: The study included 80 participants: 40 men diagnosed with AGA and 40 age-matched healthy male volunteers as a control group. The authors also divided the patient group into two subgroups: frontal AGA group and vertical AGA group. All participants were subjected to measurement of serum level of testosterone, DHT, and PSA by enzyme-linked immunosorbent assay. Results: The study revealed that the mean serum level of testosterone and DHT in patients with AGA was higher than that in the control group, and the mean serum level of testosterone in vertical AGA group was higher than that in frontal AGA group. There was no significant difference between patients and controls regarding the mean serum level of PSA. Conclusion: This study showed that serum androgens play an important role in the development of AGA, and there is a strong association between serum level of androgens and staging of AGA, whether frontal or vertical.