TY - JOUR ID - 225150 TI - Assessment of antisperm antibodies in patients with hepatitis C virus infection : A controlled study JO - Human Andrology JA - HA LA - en SN - 2090-6048 AU - Mostafa, Rashad Mahmoud AU - Soliman, Nashaat Mohamed AU - mohamed, Nourhan elsebaey AU - Saad, hany Mohammed AD - Faculty of Medicine SUEZ CANAL UNIVERSITY - FOM AD - Faculty of medicine, Suez Canal university AD - Al omraneya clinic of Dermatology AD - lecturer of andrology, faculty of medicine suez canal university, Ismalia, egypt Y1 - 2022 PY - 2022 VL - 12 IS - 12 SP - 1 EP - 6 KW - Antisperm antibody KW - Hepatitis C virus KW - Infertility DO - 10.21608/ha.2021.111879.1082 N2 - Background: Antisperm antibody (ASA) is defined as an immunoglobulin with antibody activity against a sperm antigen thatplays a role in fertility. It has been hypothesized that hepatitis C virus (HCV) infection of lymphocytes is the cause for theincreased autoimmune phenomena and autoantibody production reported in association with HCV. The development of ASAhas been previously reported in cases with human papilloma virus (HPV), where infertile males with HPV in semen showedhigher ASA percentages compared with infertile males with no HPV in semen.Aim: To investigate the influence of HCV infection on the development of ASAs in diagnosed HCV male patients.Patients and Methods: The study included two groups: group one included 25 patients who were infected with HCV, andgroup two included 25 healthy controls. Semen analyses by CASA were performedand serum and semen samples were takenfor all patients to detect ASA by enzyme-linked immunosorbent assay.Results: In the patient group, 28% were positive for ASA in semen versus 4% in the control group with a statisticallysignificant difference between the two groups (P=0.049). ASA levels in serum were positive in 36% of patients versus 12% inthe control group with a statistically significant difference between the two groups (P=0.047). There were significant negativecorrelations between progressive motility, agglutination, and the level of patient’s ASA in both serum (r=‒0.635, P<0.001,r=‒0.749, P<0.001, respectively) and semen (r=‒0.764, P=0.001; r=‒1, P<0.001, respectively).Conclusion: The coincidence of ASA in males with hepatitis C infection diseases was significantly higher than healthycontrols. UR - https://ha.journals.ekb.eg/article_225150.html L1 - https://ha.journals.ekb.eg/article_225150_f9879b8897b2eb537e60923132acd79a.pdf ER -