eng
Egyptian Society of Andrology
Human Andrology
2090-6048
2090-6056
2017-12-01
7
4
111
119
10.21608/ha.2017.1788.1015
5276
Original Article
The Global Online Sexuality Survey (GOSS) 2015: Erectile Dysfunction Among English-Speaking Internet Users in the United States
Osama Shaeer
osamashaeer@gmail.com
1
Kamal Shaeer
prof.kamalshaeer@gmail.com
2
Mikkel Fode
mikkelfode@gmail.com
3
Ege Serefoglu
egecanserefoglu@hotmail.com
4
Department of Andrology, Faculty of Medicine, Cairo University, Egypt
Department of Andrology, Faculty of Medicine, Cairo University, Egypt
Departments of Urology, University Hospital of Zealand, Roskilde and Herlev/Gentofte Hospital, Herlev, Denmark
Department of Urology, Merkez Mah. Mimar Sinan cad. 6. sok. Bagcilar, Istanbul
Introduction: The Global Online Sexuality Survey (GOSS) is an ongoing online epidemiologic study of male and female sexuality launched across the globe. The first launch was in the Middle East in 2010 followed by USA in 2011. This is the report on trends in male sexuality and prevalence and risk factors for erectile dysfunction (ED) in USA; 2015.Patients and Methods: English-speaking web surfers in the USA were recruited for GOOS 2015 by an international online survey service provider, with age and ethnicity distribution matching that of the general US population. A total of 100 questions were offered to the participants, including the abbreviated international index of erectile function, risk factors for ED, ejaculatory function, therapeutic trends, sexual preferences and sexual orientation.Results: A total of 610 men with a median age of 44 years (range 18-82). Of the participants, 90.2% described themselves as exclusively or predominantly heterosexual and 52.3% were married whereas 20.1% had multiple partners simultaneously, 54% had experienced one-night stands, with 33% never or rarely using condom on those occasions. ED was encountered in 55.4% of the participants. Some risk factors had a statistically significant influence on ED prevalence including diabetes, smoking, low desire, dissatisfaction with penile size and multiplicity of partners.Conclusion: ED seems to affect 55.4 % of males in USA; in 2015, with an association to diabetes mellitus, obesity, hypothyroidism, subjective impression of having premature ejaculation, low desire, difficult urination, smoking, dissatisfaction with penile size and multiplicity of partners, with emphasis on online cohorts being heavily weighted towards younger and better educated individuals (only 2.1% in the age of 60 and up).
https://ha.journals.ekb.eg/article_5276_856835e5a843b39948a4dcec42bb866c.pdf
Epidemiology
Survey
Erectile dysfunction
United States of America
prevalence
eng
Egyptian Society of Andrology
Human Andrology
2090-6048
2090-6056
2017-12-01
7
4
120
126
10.21608/ha.2017.1554.1012
5275
Original Article
Omentin-1 in serum and seminal plasma correlate with semen quality
Sahar Ismail
saharsotohy@yahoo.com
1
Ali Mahran
alimahran74@yahoo.com
2
Eman Mosaad
eman_mosaad@hotmail.com
3
Suzan ElSayed
4
Department of Dermatology, Venereology and Andrology, Faculty of Medicine Assiut University
Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Egypt
Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Egypt
Departmentof Foundational Medical Sciences, William Beaumont School of Medicine, Oakland University MI USA.
Introduction: Adipokines are differently regulated in the male reproductive tract and they were reported to affect sperm functionality. Serum omentin-1 was reported to have a range of effects on various cell types.Aim: To explore the presence of omentin-1in human semen, to investigate its relation with semen parameters in both fertile and infertile men and to compare its serum and seminal plasma levels in particular conditions such as; smoking, varicocele and leukocytospermia.Methods: Thirty nine infertile and 26 fertile men were enrolled in this case control study. They were subjected to history taking, clinical/physical examination, semen analysis, and measurement of omentin-1 in serum and seminal plasma, DNA fragmentation index (DFI) and seminal reactive oxygen species (ROS).Results: Omentin-1 was detected in all analyzed semen and serum samples (n=65). The concentration of omentin-1 was significantly higher in seminal plasma than in serum. Serum and seminal omentin-1 were positively correlated with sperm concentration and percentage of progressive motility and were negatively correlated with percentage of abnormal forms, DFI and ROS. The mean seminal plasma level of omentin-1 was significantly decreased in smokers and in patients with leukocytospermia. The mean serum level of omentin-1 was significantly decreased in patients with varicocele. Both serum and seminal omentin-1 levels were significantly lower in infertile patients than fertile men.Conclusions: Semen and serum Omentin-1 correlate with semen quality. In cases of leukocytospermia and smoking, seminal omentin-1 concentrations were decreased, suggesting that it may play a regulatory role in inflammation of the male reproductive system.
https://ha.journals.ekb.eg/article_5275_61be95f6ccc2521e64ca2d70413db424.pdf
Omentin-1
semen parameters
Infertility
Varicocele
leukocytospermia
eng
Egyptian Society of Andrology
Human Andrology
2090-6048
2090-6056
2017-12-01
7
4
127
135
10.21608/ha.2017.1628.1014
5277
Original Article
NRF2 gene expression and DNA fragmentation markers as possible predictors of chronic smoking induced spermatozoa dysfunction in infertility with normal seminogram
Ayman Elsamanoudy
ayman.elsamanoudy@gmail.com
1
Dalia Shaalan
daliashaalan@yahoo.com
2
Salwa Abo El-khair
dr.salwakhair@gmail.com
3
mohammad gaballah
mohali212@yahoo.com
4
Ahmed State
ahmedstate75@gmail.com
5
Ahmed Helaly
helalyahmad@hotmail.com
6
Medical Biochemistry and Molecular Biology department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Clinical
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University,Mansoura, Egypt
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University,Mansoura, Egypt
dermatology, andrology and STDs department mansoura faculty of medicine mansoura Egypt
Dermatology, Andrology & STDs Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University
Introduction: Male factor is responsible for about half of infertility problems. However, the reasons for the decrease in male fertility are still broadly unclear. The mechanisms of how smoking may impact male fertility have not been established. However, with its influence on different semen parameters, it is regarded as a risk factor for infertility.Aim: To investigate the effect of chronic smoking on spermatozoa NRF2 expression and DNA fragmentation in infertile men with apparently normal seminogram and to determine if NRF2 expression and DNA fragmentation markers could be possible predictors of the impact of chronic cigarette smoking on male fertility.Methods: Semen samples were collected from 170 subjects; 65 nonsmokers (40 fertile and 25 infertile) and 105 smokers (25 fertile and 80 infertile). NRF2 gene expression, 8-OHdG and DNA fragmentation were assayed.Results: There were significant increases in 8-OHdG and %DNA fragmentation with a significant decrease in NRF2 gene expression in infertile smokers. ROC curve analysis of spermatozoa NRF2 gene expression showed 95% sensitivity 93.3% specificity at cutoff value ≤0. 931 (p <0.0001) differentiating infertile smokers from controls. Moreover, seminal 8-OHdG assay shows 93.4% sensitivity, 89.2% % specificity, at cutoff values >19.33 pg/ml predicting the detrimental effect of smoking on spermatozoa DNA.Conclusion: Chronic cigarette smoking may be a hidden causative mechanism of delayed fertility. Spermatozoa NRF2 gene expression and seminal 8-OHdG levels may serve as sensitive diagnostic indicators predicting smoking induced infertility. So, the presence of normal seminal parameters could not be an exclusion of potential effect of chronic smoking on male fertility.
https://ha.journals.ekb.eg/article_5277_6a30e5b11af2005a4ce7e01cf8569b7a.pdf
Nrf2
DNA fragmentation
Male infertility
Smoking
eng
Egyptian Society of Andrology
Human Andrology
2090-6048
2090-6056
2017-12-01
7
4
136
142
10.21608/ha.2017.1189.1006
5278
Original Article
Time and dose-dependent adverse effects of four medicinal plants on male reproductive system
Ehsanollah Sakhaee
ehsan_sakhaee@yahoo.com
1
Ladan Emadi
emadil@yahoo.com
2
Heydar Bagaloy
3
Najma Abbasi
najmaabbasi@yahoo.com
4
Department of Clinical Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
Department of Basic Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
Department of Clinical Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
Veterinary Organization of Kerman province, Kerman, Iran.
Introduction: the point of the present survey was to evaluate time and dose-dependent adverse effects of four restorative herbs on male reproductive system.Methods: the study involved of seventeen distinctive gatherings of ten mice as takes after: group C1 to C4 (Cuminum cyminum), which received 0.1 ml Cuminum cyminum essential oil at dosage of 0.1, 1, 10 and 100 mg/kg/day, respectively. Group R1 to R4 (Rosa damascene), which received 0.1 ml Rosa damascene essential oil at dosage of 0.1, 1, 10 and 100 mg/kg/day, respectively. Group Z1 to Z4 (Zataria multiflora), which received 0.1 ml Zataria multiflora ethanolic extract at dosage of 100, 200, 400 and 800 mg/kg/day, respectively. Group O1 to O4 (Origanum vulgare), which received 0.1 ml Origanum vulgare ethanolic extract at dose of 100, 200, 400 and 800 mg/kg/day, respectively and finally group Normal which got similar amount of normal saline.Results: the results demonstrated that sperm density, mobility and viability in groups R4, O4, Z2, Z3, Z4, C2, C3 and C4 after 4 weeks were altogether diminished in comparison with normal group.Discussion: according to the results, mentioned medicinal plants should not be used frequently for prolonged duration
https://ha.journals.ekb.eg/article_5278_a79a5d58674e7b16d05e081a0e0ee189.pdf
Sperm quality
Medicinal plant
Adverse effects
Mice
eng
Egyptian Society of Andrology
Human Andrology
2090-6048
2090-6056
2017-12-01
7
4
143
153
10.21608/ha.2017.4546
5279
Original Article
Prevalence, Risk Factors and Women's Attitude towards Female Sexual Dysfunction in Upper Egypt: Hospital based study
Sahar Ismail
saharsotohy@yahoo.com
1
Nagwa Abdel-Azim
nagwaeasa@yahoo.com
2
Dina Habib
dina.habib50@aun.edu.eg
3
Mariam Zaky
4
Medhat Saleh
medhatelaraby75@yahoo.com
5
Ahmed Abbas
bmr90@hotmail.com
6
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt
Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
Objective: to investigate the prevalence and possible risk factors that may cause FSD in Upper Egypt women and to study their attitude towards their sexual dysfunction. Study design: a cross sectional hospital based study setting: Assiut University Hospital, Assiut, Egypt. Materials and methods: We included consecutive healthy sexually active Egyptian women aged between 18 and 55 years who had visited the hospital for routine check-up, women accompanying other patients and non medical female hospital staff. We used the Arabic version of the Female Sexual Function Index (Ar-FSFI) in the interview to evaluate the sexual functions or problems during the last month. The cut-off score used to indicate sexual dysfunction was 28.1. Results: a total of 583 healthy sexually active married females were approached, of whom 500 (85.8%) accepted to participate in the study. About 339 women (67.8%) had sexual dysfunction. The total mean FSFI score for women with sexual dysfunction was 16.73±7.50 compared to 31.31±1.43 for women without sexual dysfunction (p<0.001). FSD was significantly more common in older (p=0.000), less educated women (p=0.000), house wives (p=0.000) and women who live in rural communities (p=0.009). Logistic regression using the risk factors for the presence of FSD was performed. Age, residence, level of education, menopause, number of children, duration of marriage and the use of contraception were statistically significant risk factors that may predict the presence of FSD in participating women.Conclusions: The reported high prevalence of FSD indicates that sexual dysfunction is an important public health problem in Upper Egypt that has not been investigated. It highlights the need to establish sexual disorders clinics in our environment and to improve physicians’ awareness and competency in FSD
https://ha.journals.ekb.eg/article_5279_46c5bd5c00f378bc335b36b870532c5d.pdf
Arousal
desire
FSFI
sexual dysfunction
orgasm