@article { author = {Shaeer, Osama and Shaeer, Kamal and Fode, Mikkel and Serefoglu, Ege}, title = {The Global Online Sexuality Survey (GOSS) 2015: Erectile Dysfunction Among English-Speaking Internet Users in the United States}, journal = {Human Andrology}, volume = {7}, number = {4}, pages = {111-119}, year = {2017}, publisher = {Egyptian Society of Andrology}, issn = {2090-6048}, eissn = {2090-6056}, doi = {10.21608/ha.2017.1788.1015}, abstract = {Introduction: The Global Online Sexuality Survey (GOSS) is an ongoing online epidemiologic study of male and female sexuality launched across the globe. The first launch was in the Middle East in 2010 followed by USA in 2011. This is the report on trends in male sexuality and prevalence and risk factors for erectile dysfunction (ED) in USA; 2015.Patients and Methods: English-speaking web surfers in the USA were recruited for GOOS 2015 by an international online survey service provider, with age and ethnicity distribution matching that of the general US population. A total of 100 questions were offered to the participants, including the abbreviated international index of erectile function, risk factors for ED, ejaculatory function, therapeutic trends, sexual preferences and sexual orientation.Results: A total of 610 men with a median age of 44 years (range 18-82). Of the participants, 90.2% described themselves as exclusively or predominantly heterosexual and 52.3% were married whereas 20.1% had multiple partners simultaneously, 54% had experienced one-night stands, with 33% never or rarely using condom on those occasions. ED was encountered in 55.4% of the participants. Some risk factors had a statistically significant influence on ED prevalence including diabetes, smoking, low desire, dissatisfaction with penile size and multiplicity of partners.Conclusion: ED seems to affect 55.4 % of males in USA; in 2015, with an association to diabetes mellitus, obesity, hypothyroidism, subjective impression of having premature ejaculation, low desire, difficult urination, smoking, dissatisfaction with penile size and multiplicity of partners, with emphasis on online cohorts being heavily weighted towards younger and better educated individuals (only 2.1% in the age of 60 and up).}, keywords = {Epidemiology,Survey,Erectile dysfunction,United States of America,prevalence}, url = {https://ha.journals.ekb.eg/article_5276.html}, eprint = {https://ha.journals.ekb.eg/article_5276_856835e5a843b39948a4dcec42bb866c.pdf} } @article { author = {Ismail, Sahar and Mahran, Ali and Mosaad, Eman and ElSayed, Suzan}, title = {Omentin-1 in serum and seminal plasma correlate with semen quality}, journal = {Human Andrology}, volume = {7}, number = {4}, pages = {120-126}, year = {2017}, publisher = {Egyptian Society of Andrology}, issn = {2090-6048}, eissn = {2090-6056}, doi = {10.21608/ha.2017.1554.1012}, abstract = {Introduction: Adipokines are differently regulated in the male reproductive tract and they were reported to affect sperm functionality. Serum omentin-1 was reported to have a range of effects on various cell types.Aim: To explore the presence of omentin-1in human semen, to investigate its relation with semen parameters in both fertile and infertile men and to compare its serum and seminal plasma levels in particular conditions such as; smoking, varicocele and leukocytospermia.Methods: Thirty nine infertile and 26 fertile men were enrolled in this case control study. They were subjected to history taking, clinical/physical examination, semen analysis, and measurement of omentin-1 in serum and seminal plasma, DNA fragmentation index (DFI) and seminal reactive oxygen species (ROS).Results: Omentin-1 was detected in all analyzed semen and serum samples (n=65). The concentration of omentin-1 was significantly higher in seminal plasma than in serum. Serum and seminal omentin-1 were positively correlated with sperm concentration and percentage of progressive motility and were negatively correlated with percentage of abnormal forms, DFI and ROS. The mean seminal plasma level of omentin-1 was significantly decreased in smokers and in patients with leukocytospermia. The mean serum level of omentin-1 was significantly decreased in patients with varicocele. Both serum and seminal omentin-1 levels were significantly lower in infertile patients than fertile men.Conclusions: Semen and serum Omentin-1 correlate with semen quality. In cases of leukocytospermia and smoking, seminal omentin-1 concentrations were decreased, suggesting that it may play a regulatory role in inflammation of the male reproductive system.}, keywords = {Omentin-1,semen parameters,Infertility,Varicocele,leukocytospermia}, url = {https://ha.journals.ekb.eg/article_5275.html}, eprint = {https://ha.journals.ekb.eg/article_5275_61be95f6ccc2521e64ca2d70413db424.pdf} } @article { author = {Elsamanoudy, Ayman and Shaalan, Dalia and Abo El-khair, Salwa and gaballah, mohammad and State, Ahmed and Helaly, Ahmed}, title = {NRF2 gene expression and DNA fragmentation markers as possible predictors of chronic smoking induced spermatozoa dysfunction in infertility with normal seminogram}, journal = {Human Andrology}, volume = {7}, number = {4}, pages = {127-135}, year = {2017}, publisher = {Egyptian Society of Andrology}, issn = {2090-6048}, eissn = {2090-6056}, doi = {10.21608/ha.2017.1628.1014}, abstract = {Introduction: Male factor is responsible for about half of infertility problems. However, the reasons for the decrease in male fertility are still broadly unclear. The mechanisms of how smoking may impact male fertility have not been established. However, with its influence on different semen parameters, it is regarded as a risk factor for infertility.Aim: To investigate the effect of chronic smoking on spermatozoa NRF2 expression and DNA fragmentation in infertile men with apparently normal seminogram and to determine if NRF2 expression and DNA fragmentation markers could be possible predictors of the impact of chronic cigarette smoking on male fertility.Methods: Semen samples were collected from 170 subjects; 65 nonsmokers (40 fertile and 25 infertile) and 105 smokers (25 fertile and 80 infertile). NRF2 gene expression, 8-OHdG and DNA fragmentation were assayed.Results: There were significant increases in 8-OHdG and %DNA fragmentation with a significant decrease in NRF2 gene expression in infertile smokers. ROC curve analysis of spermatozoa NRF2 gene expression showed 95% sensitivity 93.3% specificity at cutoff value ≤0. 931 (p <0.0001) differentiating infertile smokers from controls. Moreover, seminal 8-OHdG assay shows 93.4% sensitivity, 89.2% % specificity, at cutoff values >19.33 pg/ml predicting the detrimental effect of smoking on spermatozoa DNA.Conclusion: Chronic cigarette smoking may be a hidden causative mechanism of delayed fertility. Spermatozoa NRF2 gene expression and seminal 8-OHdG levels may serve as sensitive diagnostic indicators predicting smoking induced infertility. So, the presence of normal seminal parameters could not be an exclusion of potential effect of chronic smoking on male fertility.}, keywords = {Nrf2,DNA fragmentation,Male infertility,Smoking}, url = {https://ha.journals.ekb.eg/article_5277.html}, eprint = {https://ha.journals.ekb.eg/article_5277_6a30e5b11af2005a4ce7e01cf8569b7a.pdf} } @article { author = {Sakhaee, Ehsanollah and Emadi, Ladan and Bagaloy, Heydar and Abbasi, Najma}, title = {Time and dose-dependent adverse effects of four medicinal plants on male reproductive system}, journal = {Human Andrology}, volume = {7}, number = {4}, pages = {136-142}, year = {2017}, publisher = {Egyptian Society of Andrology}, issn = {2090-6048}, eissn = {2090-6056}, doi = {10.21608/ha.2017.1189.1006}, abstract = {Introduction: the point of the present survey was to evaluate time and dose-dependent adverse effects of four restorative herbs on male reproductive system.Methods: the study involved of seventeen distinctive gatherings of ten mice as takes after: group C1 to C4 (Cuminum cyminum), which received 0.1 ml Cuminum cyminum essential oil at dosage of 0.1, 1, 10 and 100 mg/kg/day, respectively. Group R1 to R4 (Rosa damascene), which received 0.1 ml Rosa damascene essential oil at dosage of 0.1, 1, 10 and 100 mg/kg/day, respectively. Group Z1 to Z4 (Zataria multiflora), which received 0.1 ml Zataria multiflora ethanolic extract at dosage of 100, 200, 400 and 800 mg/kg/day, respectively. Group O1 to O4 (Origanum vulgare), which received 0.1 ml Origanum vulgare ethanolic extract at dose of 100, 200, 400 and 800 mg/kg/day, respectively and finally group Normal which got similar amount of normal saline.Results: the results demonstrated that sperm density, mobility and viability in groups R4, O4, Z2, Z3, Z4, C2, C3 and C4 after 4 weeks were altogether diminished in comparison with normal group.Discussion: according to the results, mentioned medicinal plants should not be used frequently for prolonged duration}, keywords = {Sperm quality,Medicinal plant,Adverse effects,Mice}, url = {https://ha.journals.ekb.eg/article_5278.html}, eprint = {https://ha.journals.ekb.eg/article_5278_a79a5d58674e7b16d05e081a0e0ee189.pdf} } @article { author = {Ismail, Sahar and Abdel-Azim, Nagwa and Habib, Dina and Zaky, Mariam and Saleh, Medhat and Abbas, Ahmed}, title = {Prevalence, Risk Factors and Women's Attitude towards Female Sexual Dysfunction in Upper Egypt: Hospital based study}, journal = {Human Andrology}, volume = {7}, number = {4}, pages = {143-153}, year = {2017}, publisher = {Egyptian Society of Andrology}, issn = {2090-6048}, eissn = {2090-6056}, doi = {10.21608/ha.2017.4546}, abstract = {Objective: to investigate the prevalence and possible risk factors that may cause FSD in Upper Egypt women and to study their attitude towards their sexual dysfunction.  Study design: a cross sectional hospital based study setting: Assiut University Hospital, Assiut, Egypt.  Materials and methods: We included consecutive healthy sexually active Egyptian women aged between 18 and 55 years who had visited the hospital for routine check-up, women accompanying other patients and non medical female hospital staff. We used the Arabic version of the Female Sexual Function Index (Ar-FSFI) in the interview to evaluate the sexual functions or problems during the last month. The cut-off score used to indicate sexual dysfunction was 28.1.  Results: a total of 583 healthy sexually active married females were approached, of whom 500 (85.8%) accepted to participate in the study. About 339 women (67.8%) had sexual dysfunction. The total mean FSFI score for women with sexual dysfunction was 16.73±7.50 compared to 31.31±1.43 for women without sexual dysfunction (p<0.001). FSD was significantly more common in older (p=0.000), less educated women (p=0.000), house wives (p=0.000) and women who live in rural communities (p=0.009). Logistic regression using the risk factors for the presence of FSD was performed. Age, residence, level of education, menopause, number of children, duration of marriage and the use of contraception were statistically significant risk factors that may predict the presence of FSD in participating women.Conclusions: The reported high prevalence of FSD indicates that sexual dysfunction is an important public health problem in Upper Egypt that has not been investigated. It highlights the need to establish sexual disorders clinics in our environment and to improve physicians’ awareness and competency in FSD}, keywords = {Arousal,desire,FSFI,sexual dysfunction,orgasm}, url = {https://ha.journals.ekb.eg/article_5279.html}, eprint = {https://ha.journals.ekb.eg/article_5279_46c5bd5c00f378bc335b36b870532c5d.pdf} }